A 31-year-old male client has come to the PMHNP for a medication follow-up. He tells the prescriber he is feeling "very good" on escitalopram (Lexapro). He feels so good, in fact, that he has decided to add the supplement tryptophan to his medication regimen to "boost" its effect. What is the most appropriate response by the PMHNP?

"I'm proud to see you are taking control of your health."

"That sounds very positive, and there is some evidence tryptophan does help with depression."

"I'm pleased you are doing well on your medication, but it could be dangerous to combine the supplement with the antidepressant."

"That was not a very smart thing to do. You should have talked to me before you started any new over-the-counter product."