A 39-year-old White woman tested positive for antinuclear antibody (ANA) after demonstrating signs of systemic lupus erythematosus (SLE). What is the pathogenesis of SLE?

Inappropriate treatment of Strep throat and scarlet fever infections

Genetic predisposition in the setting of environmental and/or stochastic triggers, leading to innate immune system activation

Infection with Epstein-Barr virus

Infection with human papillomavirus (HPV)