A 48-year-old man with a new diagnosis of chronic low back pain requests a prescription for opioids. Which of the following is the most appropriate response?

“Guidelines recommend nonpharmacologic therapies as first-line treatments for chronic low back pain.”

“Opioids are only recommended when other treatments are ineffective.”

“As a nurse practitioner, I cannot prescribe opioid medications.”

“I can prescribe opioids only after you have completed a comprehensive screening for addiction.”