A 52-year-old woman with a BMI of 31 is diagnosed with osteoarthritis of the knee. The nurse practitioner (NP) instructs the woman that weight loss will help minimize both pain and functional loss. Which of the following most closely explains the NP's advice to lose weight?

Weight loss is encouraged for the overall health of the patient because it reduces the chance of developing diabetes and other cardiometabolic issues

Each pound of weight loss can decrease the load across the knee 3 to 6-fold

Weight loss can reduce cardiovascular strain

Weight loss can reduce the chance for a fall, which might lead to additional damage to the knee joint