A client is receiving opioid therapy for pain management. The nurse is educating the client about the effects of long-term opioid use. Which statement by the nurse best explains the concept of drug tolerance?

“You may become addicted to the medication and need it to feel normal."

"You will not experience withdrawal symptoms if you stop taking the medication suddenly."

"You may need higher doses of the medication over time to achieve the same level of pain relief."

"You will no longer get any therapeutic effects from this drug."