A client with type 2 diabetes who has been prescribed metformin. The client asks the nurse how the medication will affect their kidneys. What is the nurse’s most appropriate response?

Metformin is generally safe for the kidneys but requires monitoring in case of renal impairment

Metformin is nephrotoxic and can directly damage your kidneys over time

Metformin increases the risk of kidney stones due to changes in urine composition

Metformin has no effect on the kidneys and does not require monitoring