A clinical trial is recommended for a female client with metastatic breast cancer, but she refuses to participate and tells her family that she does not wish to have further treatments.The client's son and daughter ask the nurse to try and convince their mother to reconsider this decision.How should the nurse respond?

Explain to the family that they must accept their mother's decision.

Discuss success of clinical trials and ask the client to consider participating for one month.

Explore the client's decision to refuse treatment and offer support.

Ask the client with her children present if she fully understands the decision she has made.