A community health nurse is preparing an in-service for staff to define the conditions of causation in epidemiology studies. Which of the following descriptions should the nurse use to define a cessation of exposure to establish causation?

"When the exposure is decreased or eliminated, the risk of disease declines or is eliminated."

"The exposure must come before the disease develops.

"A relationship is biologically possible, and it makes sense."

"Increased exposure increases the risk of developing the disease."