A community health nurse is preparing an in-service for staff to define the conditions of causation in epidemiological studies. Which of the following descriptions should the nurse use to define a temporal relationship to establish causation?

Increased exposure increases the risk of developing the disease.

The exposure must come before the disease develops.

When the exposure is decreased or eliminated, the risk of disease declines or is eliminated.

A relationship is biologically plausible, and it makes sense.