A nurse is assessing a client who has peripheral artery disease. Which of the following findings should the nurse recognize as requiring immediate intervention?

Presence of an open wound near the ankle with serous drainage and pruritus.

Lower extremities edematous with decreased pulses and cool to the touch.

Murmur auscultated at the left 5th midclavicular line, slight dyspnea, and lower extremity edema.

Pain, pallor, and paresthesia in the foot.