A nurse is assisting in the education of a group of clients about the contraindications of warfarin therapy. Which of the following statements is appropriate to include in the instructions?

"Clients who are pregnant should not take warfarin."

"Clients who have diabetes mellitus type 1 should not take warfarin."

"Clients who have hypertension should not take warfarin."

"Clients who have rheumatoid arthritis should not take warfarin."