A nurse is caring for a client who had an anaphylactic reaction after a blood transfusion. The nurse reviews the literature to further understand the type of reaction. Which of the following information should the nurse confirm about this condition?

Humoral immune response is mediated by T-lymphocytes.

Cell-mediated immunity defends only against viral infections.

Cell-mediated immunity involves phagocytic natural killer cells.

Can be triggered by antibodies reacting with proteins in the transfused blood, including IgA deficiency with anti-IgA antibodies.