A nurse is caring for a client who is receiving nitroglycerine IV and is switching to the oral form of the medication. The nurse should identify that the oral dose will be higher than the IV dose for which of the following reasons?

The oral route has lower bioavailability compared to IV administration since it has to be metabolized by the liver, necessitating a higher dose to achieve the desired effect

The IV route has decreased absorption compared to the oral route, necessitating a higher oral dose for equivalent effect.

The oral route provides more rapid onset of action compared to IV administration, requiring a higher dose for sustained effect

The oral route bypasses hepatic metabolism, leading to quicker clearance and necessitating a higher dose for sustained effect.