A nurse is caring for a patient with a confirmed Gram-negative bacterial infection. The healthcare provider has prescribed an antibiotic regimen. Which of the following considerations is most important when treating Gram-negative organisms compared to Gram-positive organisms?

A Gram-negative bacteria have a thicker peptidoglycan (cell wall), making them more susceptible to antibiotics

Gram-negative bacteria possess a multi-layered cell wall that can impede antibiotic penetration more skillfully, requiring specific antibiotic selection

Gram-negative bacteria are less likely to develop antibiotic resistance, simplifying treatment choices

Gram-negative bacteria have a thinner cell wall, making them more susceptible to antibiotic therapy.