A nurse is planning care for a hospitalized client newly prescribed antidepressant medication for major depressive disorder. Which rationale best supports the need for close monitoring during the initial phase of therapy?

Antidepressants have immediate therapeutic effects, requiring rapid dose adjustments

Clients often experience improved energy before mood lifts, increasing suicide risk

Antidepressants may cause sedation, leading to decreased fall risk in the early phase

Most clients become nonadherent due to side effects within the first 72 hours