A nurse is preparing to teach a client with a new prescription for levothyroxine about the timing of the medication. Which instruction should the nurse prioritize to ensure optimal absorption and therapeutic effect?

Take levothyroxine first thing in the morning on an empty stomach, waiting at least 30 to 60 minutes before eating or taking other medications

Take levothyroxine at bedtime immediately after eating to prevent stomach upset and improve compliance

Take levothyroxine with your second meal of the day to ensure it works through the evening

Take levothyroxine anytime during the day as long as it is consistently taken at the same time daily, regardless of meals.