A nurse is providing teaching to a client who has a new prescription for nitroglycerin transdermal patch. Which instructions should the nurse include? Select 4 that apply

Apply the patch to a hairless area

Take the old patch off, clean skin, and apply a new patch each day

Gloves are not needed for application of the patch

A nitrate-free period, typically at bedtime, is needed to prevent tolerance

Apply a new patch at the onset of aginal pain

Rotate patch sites