A nurse is providing teaching to a client who has rheumatoid arthritis and a new prescription for methotrexate. Which of the following information should the nurse provide?

Expect to have a fever for the first days of therapy.

Drink 2 to 3 L of water per day while on the medication.

Take the medication in the morning to prevent insomnia.

Administer the medication with an NSAID to enhance effectiveness.