A nurse is providing teaching to a client who has rheumatoid arthritis and a new prescription for methotrexate. Which of the following instructions should the nurse include? (Select all that apply.)

Take NSAIDs to help minimize the adverse effects of the medication.

Do not drink alcoholic beverages while taking this medication.

Expect to feel the medication's effects immediately.

Report unexplained bruising to the provider.

Avoid people who have infections.