A nurse is providing teaching to an adolescent client who has cystic fibrosis and reports increased fatigue and weight loss. Which of the following Instructions should the nurse include in the teaching?

“Include supplemental pancreatic enzymes with snacks."

“Avoid taking water-soluble vitamins with pancreatic enzymes."

"Adjust pancreatic enzymes to achieve three to four stools per day."

"Decrease pancreatic enzymes when eating high-fat meals."