A nurse is reinforcing teaching to a client who has peripheral arterial disease. Which of the following statements should the nurse include in the teaching to explain the cause of peripheral arterial disease?

"Blood flow is altered and causes blood to pool in the legs."

"Blood flow is altered due to excessive stretching of the ventricles impairing the heart to contract."

"Blood flow is altered due to atherosclerosis affecting the tissues' ability to receive oxygen-rich blood."

"Blood flow is altered due to incompetent valves causing increased venous pressure."