A nurse is reinforcing teaching with a newly licensed nurse about the administration of depot medroxyprogesterone. Which of the following instructions should the nurse include in the teaching?

"Initiate depot medroxyprogesterone 14 days after the client's first day of her menstrual cycle."

"Administer depot medroxyprogesterone every 6 to 8 weeks."

"Give the medication intramuscularly.

"Massage the site after you administer the medication."