A nurse is teaching a client who has tuberculosis and is to start medication therapy with isoniazid, rifampin and pyrazinamide. Which of the following instructions should the nurse include?

"Take isoniazid with an antacid."

"Drink at least 8 ounces of water when you take the pyrazinamide tablet."

"Expect your sputum cultures to be negative after 6 months of therapy."

"Provide a sputum specimen every 2 weeks to the clinic for testing."