A nurse manager is developing a protocol to reduce the incidence of UTIs in clients who have an indwelling urinary catheter. Which of the following interventions should the nurse include in the protocol?

Limit indwelling urinary catheter usage to 4 days.

Perform routine catheter irrigation every 8 hr

Maintain a closed system, ensuring connections are sealed securely.

Cleanse the periurethral area with antiseptic cleaning solutions