A nurse manager is developing a protocol to reduce the incidence of UTIs in clients who have an indwelling urinary catheter. Which of the following interventions should the nurse include in the protocol?

Cleanse the periurethral area with antiseptic cleaning solutions.

Perform routine catheter irrigation every 8 hrs.

Limit indwelling urinary catheter usage to 4 days.

Maintain a closed system, ensuring connections are sealed securely.