A nurse reads in a drug information guide that PO (oral) morphine has a high first-pass effect. Which of the following statements would demonstrate the nurse's understanding of the first-pass effect?

The drug will be most effective when given orally.

The drug will be more effective when given in a non-enteral route (IV, SQ).

The drug whether given oral or IV will have the same effect.

The drug is excreted by the lungs at a slower rate than most medications.