A nurse reviews a patient's medication list. The patient is taking a drug that is highly protein-bound (greater than 89 percent). Which of these best explains the significance of highly protein-bound medications?

The drug is less likely to cause toxicity in a patient with hypoalbuminemia.

A large portion of the drug is inactive and will not exert a therapeutic effect.

The drug's metabolism will be significantly slower than a low protein-bound drug.

The drug will be excreted rapidly by the kidneys.