A patient with kidney failure is prescribed a medication that is primarily excreted through the kidneys. Which of the following statements is most accurate regarding the pharmacokinetics of this medication?

Hepatic metabolism will fully compensate for the decreased renal excretion

Dose adjustment may be necessary to prevent drug accumulation

The medication's half-life will likely be shorter due to decreased renal function

The risk of drug toxicity is decreased due to impaired excretion