A patient with major depression is discharged home on anti-depressant medication. He returns to the clinic the following week reporting the medication is not working. What explanation would you provide to the patient?

Let us speak with the doctor and ask for a change to a different medication.

You probably need a higher dose to be effective.

It is important to understand starting an anti-depressant takes 4-6 weeks to take effect.

You must not have been compliant with the medication regime.