A preceptor is educating a new graduate nurse about barbiturates. The preceptor states, "Barbiturates were once widely used but are now rarely prescribed." Which follow-up statement by the preceptor best explains why barbiturates are not as commonly used today?

"Barbiturates carry a higher risk of dependence and overdose compared to other sedative-hypnotics."

"Barbiturates are more expensive than newer medications like benzodiazepines, which limits their use."

"Barbiturates have been replaced because they are less effective than over-the-counter sleep aids."

"Barbiturates are safer for long-term use compared to other sedatives, but they have limited availability."