A young man complains that he develops a runny nose and sneezes whenever he is close to cats. Which of the following mechanisms disease is the most important cause of sneezing in this patient with an environmental allergy?

Autoantibody binding to basement membrane proteins

Histamine release and binding to H1 receptors

Immune complex formation and complement activation

Neutrophil activation and degranulation

T lymphocyte activation and secretion of interferon