According to the STAR*D research trial on treating depression, which therapy would be considered the most appropriate first line drug to use?

Buspirone (Buspar) - 5HT1a Agonist

Alprazolam (Xanax) - Benzodiazepine

Amitriptyline (Elavil) - Tricyclic Antidepressant

Lexapro (Escitalopram) - Selective Serotonin Reuptake inhibitor