Anticholinergic agents, such as benztropine (Cogentin) or diphenhydramine (Benadryl), may be given with a typical antipsychotic, such as fluphenazine (Prolixin) to:

Manage extrapyramidal symptoms caused by typical antipsychotics

Potentiate and "boost" the effects of fluphenazine

Assist with the negative symptoms seen in schizophrenia

Increase CNS depression