Methotrexate is prescribed for a client with rheumatoid arthritis (RA) who is also taking aspirin. Which is the best explanation for the nurse to provide as to why a second medication has been added?

Methotrexate has less harmful side effects than aspirin.

Methotrexate helps to reduce the side effects of the aspirin therapy.

Methotrexate enhances the effectiveness of the aspirin.

Methotrexate slows the disease progression while aspirin controls the symptoms.