The head computed tomography (CT) result indicates no bleeding in the brain and the neurologist diagnoses an acute ischemic stroke and orders tPA. Select the appropriate interventions for tPA administration. (Select all that apply)

Patients must be screened for any recent history of gastrointestinal (GI) bleeding.

tPA must be given within 8 hours of the onset of signs of ischemic stroke.

tPA is a high-risk drug which requires a two-nurse verification.

Patients with embolic strokes are not candidates for tPA.

Closely monitor the patient’s vital signs and neurologic status.