The NP prescribed an SSRI for the initial treatment of a client with major depression. On a one-month follow-up visit, the client reports continued symptoms of depression. Before making a change in the client's treatment plan, which of the following is an important consideration regarding the effects of antidepressant medications?

Evidence does not support prescribing another antidepressant medication

It is unusual for the individual to continue to exhibit symptoms after one month

The lack of response to the initial antidepressant after one month requires a referral to a mental health provider

Approximately 50% of depressed individuals may not show a favorable response during initial treatment to an antidepressant drug