The NP sees a 53-year-old woman of Asian descent who has a history of smoking and a BMI of 20. The NP evaluates her for osteoporosis. What is the pathophysiology of this disease process?

Osteoporosis is a progressive disease that damages or destroys synovial joint structure and articular cartilage of the joints.

Excess osteoclastic activity is followed by compensatory osteoblastic activity, leading to the formation of bone that is less compact, mechanically weaker, and more susceptible to fracture.

Osteoporosis is an autoimmune disorder in which inflammation of the synovium leads to joint destruction and deformity.

Osteoporosis is an imbalance of bone resorption and bone remodeling that leads to decreased skeletal mass.