The nurse evaluates a client with a right leg deep vein thrombosis (DVT) to determine if treatment is effective. Which findings indicate that treatment is not therapeutic? Select all that apply.

The client's IV site where heparin is being infused has infiltrated.

The client's left calf is swollen, red, and painful

Circumference of the affected leg changed from 44 to 38 cm

The client is reporting sudden difficulty breathing and shortness of breath

The client had a small skin tear yesterday and bled for longer than normal