The nurse is administering IV fluconazole to a client who has systemic candidiasis. After reviewing the client's diagnostic studies, the nurse identifies a rising trend in the liver enzyme levels for aspartate aminotransferase (AST). Which action should the nurse implement?

Begin the infusion and monitor the client's blood urea nitrogen (BUN), serum creatinine, and liver function tests.

Hold the dose and notify the pharmacy to stop dispensing the next premixed doses.

Begin the infusion and submit a drug reaction report to the nursing supervisor.

Hold the dose and notify the healthcare provider of the changes in the laboratory studies.