The nurse is explaining Parkinson disease to the student nurse. Which statement indicates that the student nurse correctly understands the pathophysiology of the disease?

"Regardless of the actual etiology. Parkinson disease is caused by depletion of dopamine and excess of acetylcholine."

"When there is decreased dopamine uptake at receptors in brain cells, Parkinson disease results.

"The pathophysiology of the disease is caused by the deterioration of the myelin sheath of the basal ganglia."

"Excess dopamine and deficient acetylcholine are the cause of Parkinson disease