The nurse is preparing to administer medications to a 54-year-old client. Which medications taken would be affected by the first-pass effect? (Select All that Apply.)

Morphine 2mg IV (Intravenously)

Diphenhydramine (Benadryl) 25mg Tablet

Famotidine 10mg Tablet

Nitroglycerin 4mg Sublingual Tablet

Nitroglycerin 10mg Sublingual Tablet

Acetaminophen 325mg Capsule