The nurse teaches a patient who is prescribed nirmatrelvir/ritonavir (Paxlovid). Which of these should be included in the patient teaching about Paxlovid?

The patient must be 12 years or older to take Paxlovid.

Paxlovid treatment is initiated within 5 days of symptom onset.

Report to the provider if the patient develops a rash.

Inform the patient of potential alteration in taste.

Significant weight gain is an adverse reaction of Paxlovid.