The patient provides three positive responses to items on the CAGE (Cut down, Annoyed, Guilty, Eye-opener) query. What interpretation should the nurse provide to the patient?

One positive response indicates the patient should seek help with alcohol addiction.

All responses to the CAGE Questionnaire must be positive to suggest alcohol dependence.

The CAGE Questionnaire is a tool used to identify general substance abuse.

At least two positive responses are strongly suggestive of alcohol dependence.