When discussing pharmacological considerations, a 68-year-old client asks, "Why do medications seem to act differently than they did when I was you. You base the response on what concept?

Over-the-counter (OTC) drugs have standardized dosages that are appropriate for all ages.

Age-related changes affect the way drugs are metabolized by older adults.

Older adults may need larger doses of medication to bring about the desired effects.

Adverse drug reactions occur with similar frequency in older adults as the general population.