When prescribing tacrolimus (Protopic) to treat atopic dermatitis patients should be informed that:

Tacrolimus is the most effective if it is used continuously for 4 to 6 months

Tacrolimus should be spread generously over the affected area

The FDA has issued a Black Box warning about the use of tacrolimus and the development of cancer in animals and humans

The FDA recommends patients be screened for cancer before prescribing tacrolimus