Which of the following patients are at risk for developing drug toxicity? (Select all that apply.)

16-year-old female, who has had vomiting and diarrhea

65-year-old male, who has been on high doses of antibiotics for 3 weeks

75-year-old female, who swallowed Caladryl lotion

43-year-old male, who has liver failure

82-year-old male, who has renal disease