Which of the following responses indicate that the nurse understands the first-pass effect?

Medication routes that are affected by the first-pass effect include intravenous, intramuscular, and intradermal.

Enteric-coated tablets and capsules are affected by the first-pass effect except a pharmacologic effect.

The first-pass effect is when the liver activates all medications on their first pass through the liver.

Enteral medications may need a higher dose due to the first-pass effect.