Which statement should the nurse include when discussing estradiol cream with a patient experiencing post-menopausal vaginitis?

Very little hormone is absorbed systemically with cream-based preparations resulting in fewer adverse effects compared to oral estrogen replacement therapy.

This form of hormone replacement therapy is the least effective for vaginitis

Recent menopausal women should not use hormone replacement as symptoms of vaginitis may be transient

There is a higher incidence of thrombophlebitis with estradiol cream than with oral estrogen preparations